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Poster
The Effects of Dopamine on Neutrophil Cell Adhesion
University of West Florida Libraries
Summer Undergraduate Research Program (SURP) Symposium (University of West Florida, Pensacola, Florida, 08/2025)
08/2025
Abstract
Neutrophils are pivotal innate immune cells, serving as the body's first line of defense against bacterial and fungal infections. They rapidly extravasate from the bloodstream to sites of inflammation followed by chemokine-induced integrin activation and firm adhesion. A deficiency in neutrophils, known as neutropenia, severely compromises immune function, leading to recurrent and potentially life-threatening infections. Emerging research suggests an interplay with neurotransmitters like dopamine (DA) potentially modulating neutrophil behavior. Studies have indicated that dopamine can influence various immune responses, including neutrophil chemotaxis and expression of adhesion molecules, suggesting an anti-inflammatory role. This experiment aims to further analyze the impact of dopamine on neutrophil adhesion. By treating neutrophils, incubated with Calcein AM, with varying concentrations of DA, we will observe changes in their adhesive properties, thereby providing insights into the neuro-immunomodulatory effects of dopamine on critical neutrophil functions.
Details
- Title
- The Effects of Dopamine on Neutrophil Cell Adhesion
- Resource Type
- Poster
- Event
- Summer Undergraduate Research Program (SURP) Symposium (University of West Florida, Pensacola, Florida, 08/2025)
- Contributors
- Peter Cavnar (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99381555255906600
- Academic Unit
- Biology; Summer Undergraduate Research Program 2025; Hal Marcus College of Science and Engineering
- Language
- English