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Synthesis of 3-chlorobenzo[b]thiophenes via Copper-catalyzed Electrophilic Cyclization Reactions
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Synthesis of 3-chlorobenzo[b]thiophenes via Copper-catalyzed Electrophilic Cyclization Reactions

Arav Jain, Malane Qi, Georgia Ness and Peyton Stalcup
University of West Florida Libraries
Student Scholars Symposium and Faculty Research Showcase (University of West Florida, Pensacola, Florida, 04/17/2025)
04/17/2025

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Abstract

Benzo[b]thiophene scaffolds form the backbone of many pharmaceutical products. Their uses in medicinal chemistry include antidepressants, anti-inflammatories, and anti-tumor among other possibilities. In the traditional multi-step synthesis, the product needs purification after each step1,2 . This can lead to increased chemical waste and loss of product. Further exploration into this field could yield more efficient synthesis, as well as create a foundation capable of being altered with different substituents for varied applications.
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