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Poster
Synthesis and Isolation of an Orthoamide Carbocation Metalloenzyme Mimic Building Block
University of West Florida Libraries
Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2024)
08/2024
Abstract
Macrocyclic polyamines are important building blocks as ligands for biomimetic chemistry to develop inhibitors that target specific enzymes. Our goal is to synthesize 1,4,8-triazacycloundecane (TACU) (Figure 1), a small molecule mimic of the active site of a Zn(II) containing metalloenzyme, carboxypeptidase A (CPA) (Figure 1).1 In this presentation, we however report the synthesis of a carbocation intermediate (Figure 2) during the TACU synthesis in an attempt to isolate and study its X-ray crystal structure so that we can understand the possible reasons for the low literature-reported yields of 50-60% for TACU.1
Details
- Title
- Synthesis and Isolation of an Orthoamide Carbocation Metalloenzyme Mimic Building Block
- Resource Type
- Poster
- Event
- Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2024)
- Contributors
- Ajay Lajmi (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380576895306600
- Academic Unit
- Summer Undergraduate Research Program 2024; Hal Marcus College of Science and Engineering ; Chemistry
- Language
- English