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Optimization of the synthesis of Copper(I) phenylacetylide
Poster   Open access

Optimization of the synthesis of Copper(I) phenylacetylide

Valentina Duque Castano, Kian B. Muldoon, Daniel J. LeMay, Greg G. Ciangiotto and Wheeler J. Smith
University of West Florida Libraries
Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 2021)
2021

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Abstract

Copper(l) phenylacetylide is a chemical compound that plays an important role in medical chemistry, pharmaceutical manufacturing, drug development, and general chemical synthesis (1-4). It has a characteristic yellow color in the solid state, making it easy to identify. Copper(l) phenylacetylide is produced from the reaction of basic copper(l) oxide CU₂O, with the weak acid phenylacetylene in ethanol, with a sulfuric acid catalyst. Available methods for making these compound are difficult, time-consuming and require environmentally hazardous solvents. We have found a new way to synthesize Copper(l) phenylacetylide by a simple, quick and "green" synthesis. Our method offers multiple advantages, since no reducing agent is needed and air-free conditions are required during filtration. The starting materials are all available commercially a good price and the solvent used, 95% ethanol, is environmentally friendly.
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