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Poster
Identifying bacterial phage specific to calpain-mediated cleavage of the tau protein in-vitro
University of West Florida Libraries
Student Scholar Symposium & Faculty Research Showcase (University of West Florida, Pensacola, Florida, 04/20/2023)
04/20/2023
Abstract
Calpains are a family of calcium-dependent thiolproteases that selectively cleave substrates including tau, a microtubule-associated protein central to Alzheimer’s disease neuropathology. Previous work has shown that AD tau is hyperphosphorylated compared with control tau, as illustrated in Figure 1, and is resistant to calpain activity. We have used
Phage-display, a method of studying protein-protein interactions, to exploit the differences in tau found in cerebrospinal fluid (CSF) to create a biomarker detection method based on the presence or absence of calpain-cleaved tau.
Details
- Title
- Identifying bacterial phage specific to calpain-mediated cleavage of the tau protein in-vitro
- Resource Type
- Poster
- Event
- Student Scholar Symposium & Faculty Research Showcase (University of West Florida, Pensacola, Florida, 04/20/2023)
- Contributors
- Rodney P Guttmann (Faculty Mentor) - University of West Florida, Hal Marcus College of Science and EngineeringEnid E Sisskin (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380475896206600
- Academic Unit
- Biology; 2023 Student Scholars Symposium and Faculty Research Showcase; Office of Undergraduate Research; Hal Marcus College of Science and Engineering
- Language
- English