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Poster
Identifying Phage to Regulate EGF Receptor Activity to Kill Cancer Cells
University of West Florida Libraries
Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2023)
10/14/2023
Abstract
Receptor Tyrosine Kinases (RTKs) are a form of cell surface receptor that are crucial in several cellular processes, including cell proliferation, survival, and differentiation. Their significance in cell biology is why abnormal RTK function is associated with numerous human disease processes, including cancers. Through the understanding of RTK function and signaling, the behavior of these receptors can be altered to cause either hyperactivity or inhibition. This project aimed to use the 7-mer bacteriophage library to inhibit the epidermal growth factor (EGF) receptor tyrosine kinase. Several malignant tumors, such as breast, ovarian, and most notably, non-small cell lung cancer show signs of overactive EGFR behavior. By developing a process by which only these hyperactive dysfunctional EGF RTKs are targeted, noninvasive and highly specific cancer therapy could be developed to treat these diseases.
Details
- Title
- Identifying Phage to Regulate EGF Receptor Activity to Kill Cancer Cells
- Resource Type
- Poster
- Event
- Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2023)
- Contributors
- Rodney P Guttmann (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries to digitize and/or display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380472470506600
- Academic Unit
- Summer Undergraduate Research Program 2023; Hal Marcus College of Science and Engineering ; Biology
- Language
- English