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Poster
Effects of Metformin on Acute Doxorubicin-Induced Cardiotoxicity
University of West Florida Libraries
Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2024)
08/2024
Abstract
Doxorubicin (DOX) is an efficient antineoplastic chemotherapeutic drug utilized in the treatment of many different types of cancer. Unfortunately, DOX treatment is a double-edged sword, leading to heart failure in up to 9% of cases. Cardiotoxicity caused by DOX treatment can be defined as acute, subacute, or chronic. DOX-induced cardiotoxicity (DIC) is multifaceted, with evidence suggesting that DOX leads to an increase in oxidative stress, loss of mitochondria, altered autophagy, and premature senescence. DOX-induced heart is dose-dependent, leading to a decrease in the lifetime dose prescribed to cancer patients. The need for a co-treatment to reduce DIC is paramount in ensuring cancer patients receive the therapeutic dose of DOX. A candidate for co-treatment would need to be safe, well-tolerated, and provide no interference with DOX treatment. It is theorized that endurance exercise would be the optimal pre-treatment, as the relationship with cardio-protection is well understood. However, in patients who are not capable of performing exercise prior to DOX treatment, pharmacologic intervention is required. AICAR is a widely studied exercise mimetic used in in-vitro experiments. Evidence showing the potentially harmful effects of AICAR treatment necessitated alternative considerations. Metformin (MET) was a great candidate as literature showed the potential cardioprotective effects and safety of the drug. In this study, metformin pretreatment was administered to rat cardiomyocytes (H9C2 cell line) for two hours, followed by doxorubicin treatment for 24 hours. Increased apoptosis and oxidative stress were observed in cells treated with doxorubicin; however, no cardiac protection was observed in cells pretreated with metformin.
Details
- Title
- Effects of Metformin on Acute Doxorubicin-Induced Cardiotoxicity
- Resource Type
- Poster
- Event
- Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2024)
- Contributors
- Youngil Lee (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries by the author to digitize and/or display this information for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380576893506600
- Academic Unit
- Summer Undergraduate Research Program 2024; Usha Kundu, MD College of Health
- Language
- English