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Poster
Characterization of the Atypical Antipsychotic Effect on Neutrophil Viability through Dopamine Receptor Signaling
University of West Florida Libraries
Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2023)
10/14/2023
Abstract
Neutrophils are the immune system's first line of defense against infections and bacteria, and they alone make up about 70% of the leukocytes in the human body. The lack of neutrophils is called neutropenia and can be caused by certain medications. The atypical antipsychotic aripiprazole is seen in a small subset of patients to be a cause of this drug induced neutropenia. Dopamine has been found to be present in many tissues like bone marrow, suggesting that immune cells are regulated by dopamine. However, there is differing reports on whether human neutrophils have the five dopamine receptors, and it is unknown if the cell line PLB-985, a human myeloid leukemia cell line that can be differentiated into neutrophils using DMSO, will have the dopamine receptors. The results found that of five dopamine receptors, DRD3 and DRD5 were found to be present on the cell, and that Aripiprazole's effect is through a dopamine receptor independent mechanism.
Details
- Title
- Characterization of the Atypical Antipsychotic Effect on Neutrophil Viability through Dopamine Receptor Signaling
- Resource Type
- Poster
- Event
- Summer Undergraduate Research Program (University of West Florida, Pensacola, Florida, 08/2023)
- Contributors
- Peter Cavnar (Faculty Mentor)
- Publisher
- University of West Florida Libraries; Argo Scholar Commons
- Format
- pdf
- Copyright
- Permission granted to the University of West Florida Libraries to digitize and/or display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires the permission of the copyright holder.
- Identifiers
- 99380472262006600
- Academic Unit
- Summer Undergraduate Research Program 2023; Hal Marcus College of Science and Engineering ; Biology
- Language
- English