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Prevalence of Osteoarthritis Among Individuals with a History of Knee Injury: Insights from the Osteoarthritis Initiative
Conference presentation

Prevalence of Osteoarthritis Among Individuals with a History of Knee Injury: Insights from the Osteoarthritis Initiative

Armaghan Mahmoudian, Karishma S Chhabria and Achraf Cohen
APHA 2025: Making the public's health a national priority (Washington, D.C, USA, 11/02/2025–11/05/2025)
11/02/2025

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Abstract

Background: Osteoarthritis (OA) affects over 32.5 million U.S. adults, with knee injuries being a significant risk factor. Limited research has examined this associated, hence this study estimates the prevalence of injury-related knee OA using data from the Osteoarthritis Initiative (OAI), a large publicly available population-based cohort. Methods: Individuals with and without a history of knee injury were identified, and the presence of radiographic knee OA was assessed using the Kellgren and Lawrence grading system (grade ≥2). Logistic regression models were applied to assess the association between prior knee injury and OA, adjusting for age, sex, and body mass index (BMI). Results: In the OAI cohort (n = 4415), 28.5% of participants reported a history of knee injury. Among those individuals, 55.3% had radiographic evidence of structural OA. Logistic regression revealed, those with knee injury were 2.1 times (CI: 1.8–2.4) more likely to have OA as compared to those without knee injury. Further, men were 21% less likely to be diagnosed with OA as compared to females (CI: 0.7-0.9). Conclusion: These findings reinforce the strong association between knee injuries and presence of structural OA. The results underscore the need for targeted preventive strategies, including injury prevention, early rehabilitation, and risk-based screening protocols, to reduce the long-term burden of OA. Future research should prioritize longitudinal data and diverse populations to better understand causal pathways and intervention opportunities.

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